PI3K-mTOR in Cancer and Cancer Therapy

PI3K-mTOR in Cancer and Cancer Therapy

AngličtinaPevná väzbaTlač na objednávku
Springer, Berlin
EAN: 9783319342092
Tlač na objednávku
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Podrobné informácie

In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway’s involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance.   Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.​
EAN 9783319342092
ISBN 3319342096
Typ produktu Pevná väzba
Vydavateľ Springer, Berlin
Dátum vydania 22. júna 2016
Stránky 294
Jazyk English
Rozmery 235 x 155
Krajina Switzerland
Čitatelia General
Ilustrácie XXIV, 294 p. 31 illus. in color.
Editori De Pradip; Dey Nandini; Leyland-Jones Brian
Edícia 1st ed. 2016
Séria Cancer Drug Discovery and Development