Paroxysmal Nocturnal Hemoglobinuria and Related Disorders

Paroxysmal Nocturnal Hemoglobinuria and Related Disorders

EnglishHardback
Springer Verlag, Japan
EAN: 9784431703297
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Few publications focus on the mysterious, genetically acquired disease paroxysmal nocturnal hemoglobinuria (PNH) and the related "intractable" disorders—aplastic anemia and myelodysplastic syndromes. Now, however, the latest understanding of the clinical and molecular genetic aspects of PNH is summarized here in the proceedings of the International Symposium held in Tokyo in 2001. Major topics reviewed include the molecular mechanisms of the PIG-A gene mutation; complement activation and inhibitors; experimental animal models; pathogenesis; the history of PNH research; the natural history of the disease; the mechanism of PNH clone expansion; the emergence of PNH clones under bone marrow failure syndromes; and treatment of the disease by immunosuppressive agents and stem cell transplantation. This book provides an invaluable summary of current research on the fundamental aspects of PNH pathology, presented by renowned experts in the field.

 

EAN 9784431703297
ISBN 4431703292
Binding Hardback
Publisher Springer Verlag, Japan
Publication date December 9, 2002
Pages 285
Language English
Dimensions 235 x 155
Country Japan
Readership Professional & Scholarly
Illustrations XVIII, 285 p.
Editors Kinoshita, T.; Omine, M.
Edition 2003 ed.