Evaluation of Analgesic Activity of Datura leaves in Albino Rats

The current study is based on Evaluation of Analgesic Activity of Datura Stramonium leaves in Albino Rats. Datura stramonium is belongs to the family solanaceae is mostly found throughout the globe. The hydro alcoholic extracts are used traditionally as a potent analgesic during surgery or bone setting. The aim of the present investigation is to evaluate the analgesic activity of hydro alcoholic leaf extract of Datura stramonium in albino rats. The experiment was performed by inducing Datura stramonium extracts in two different concentrations to test groups by using hot plate method for analgesic study and compared with Tramadol HCL at 40 mg/Kg IP body weight intraperitoneally as reference drugs. The results of hot plate method indicates a dose dependent effect for both the doses of Datura stramonium resembling that of Tramadol HCL in their anti nociceptive effect versus time indicating that the extract have a central analgesic effect probably by both narcotic and non narcotic mechanisms which may be due to various phytochemical contents present in the leaf of the plant Datura stramonium.