Bayesian Designs for Phase I-II Clinical Trials

Bayesian Designs for Phase I-II Clinical Trials

EnglishHardbackPrint on demand
Yuan Ying
Taylor & Francis Inc
EAN: 9781498709552
Print on demand
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Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources.

Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes.

Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.

EAN 9781498709552
ISBN 1498709559
Binding Hardback
Publisher Taylor & Francis Inc
Publication date June 22, 2016
Pages 324
Language English
Dimensions 234 x 156
Country United States
Authors Nguyen Hoang Q.; Thall Peter F.; Yuan Ying
Illustrations 63 Tables, black and white; 40 Illustrations, black and white
Series Chapman & Hall/CRC Biostatistics Series